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1

C-6α vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which is Better? Synthesis, Biochemical Evaluation, Docking Studies and Structure-Activity Relationships

Roleira, Fernanda Maria Fernandes, Varela, Carla, Amaral, Cristina, Costa, Saul C., Correia-da-Silva, Georgina, Moraca, Federica, Costa, Giosuè, Alcaro, Stefano, Teixeira, Natercia Almeida, Tavares da

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 979 KB

english, 2019

2

Acquired-resistance to aromatase inhibitors: where we stand!

Augusto, Tiago, Correia-da-Silva, Georgina, Rodrigues, Cecília . M.p, Teixeira, Natércia, Amaral, Cristina

Journal:

Endocrine Related Cancer

Year:

2018

Language:

english

File:

PDF, 1.50 MB

english, 2018

3

Anti-Inflammatory Effect of Unsaturated Fatty Acids and Ergosta-7,22-dien-3-ol from Marthasterias glacialis: Prevention of CHOP-Mediated ER-Stress and NF-κB Activation

Pereira, David M., Correia-da-Silva, Georgina, Valentão, Patrícia, Teixeira, Natércia, Andrade, Paula B., Kalin, Tanya V.

Journal:

Year:

2014

Language:

english

File:

PDF, 7.18 MB

english, 2014

4

Chemical composition and anti-cancer properties of Juniperus oxycedrus L. essential oils on estrogen receptor-positive breast cancer cells

El-Abid, Hassan, Amaral, Cristina, Cunha, Sara C., Augusto, Tiago V., Fernandes, José O., Correia-da-Silva, Georgina, Teixeira, Natércia, Moumni, Mohieddine

Journal:

Journal of Functional Foods

Year:

2019

Language:

english

File:

PDF, 2.28 MB

english, 2019

5

Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling

Almada, Marta, Amaral, Cristina, Oliveira, Ana, Fernandes, Pedro Alexandrino, Ramos, Maria João, Fonseca, Bruno, Correia-da-Silva, Georgina, Teixeira, Natercia

Journal:

Reproductive Toxicology

Year:

2020

Language:

english

File:

PDF, 2.60 MB

english, 2020

6

Cannabis sativa: Much more beyond Î9-tetrahydrocannabinol

Alves, PatrÃcia, Amaral, Cristina, Teixeira, NatÃ©rcia, Correia-da-Silva, Georgina

Journal:

Pharmacological Research

Year:

2020

File:

PDF, 6.57 MB

2020

7

Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta

Maia, JoÃ£o, Fonseca, Bruno M., Cunha, Sara C., Braga, Jorge, GonÃ§alves, Daniela, Teixeira, NatÃ©rcia, Correia-da-Silva, Georgina

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2020

File:

PDF, 2.67 MB

2020

8

Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs

Almeida, Cristina Ferreira, Teixeira, NatÃ©rcia, Oliveira, Ana, Augusto, Tiago V., Correia-da-Silva, Georgina, Ramos, Maria JoÃ£o, Fernandes, Pedro Alexandrino, Amaral, Cristina

Journal:

Year:

2021

File:

PDF, 1.30 MB

2021

9

New steroidal aromatase inhibitors: Suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death

Margarida Cepa, Georgina Correia-da-Silva, Elisiário J Tavares da Silva, Fernanda MF Roleira, Margarida Borges, Natércia A Teixeira

Journal:

BMC Cell Biology

Year:

2008

Language:

english

File:

PDF, 10.70 MB

english, 2008

10

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

Varela, Carla, Tavares da Silva, Elisiário J., Amaral, Cristina, Correia da Silva, Georgina, Baptista, Teresa, Alcaro, Stefano, Costa, Giosuè, Carvalho, Rui A., Teixeira, Natércia A. A., Roleira, Fern

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 461 KB

english, 2012

11

Structure−Activity Relationships of New A,D-Ring Modified Steroids as Aromatase Inhibitors: Design, Synthesis, and Biological Activity Evaluation

Cepa, Margarida M. D. S., Tavares da Silva, Elisiário J., Correia-da-Silva, Georgina, Roleira, Fernanda M. F., Teixeira, Natércia A. A.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

12

Synthesis and biochemical studies of 17-substituted androst-3-enes and 3,4-epoxyandrostanes as aromatase inhibitors

Margarida M.D.S. Cepa, Elisiário J. Tavares da Silva, Georgina Correia-da-Silva, Fernanda M.F. Roleira, Natércia A.A. Teixeira

Journal:

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

13

Characterisation of the endocannabinoid system in rat haemochorial placenta

Bruno M. Fonseca, Georgina Correia-da-Silva, Anthony H. Taylor, Patricia M.W. Lam, Timothy H. Marczylo, Justin C. Konje, Natércia A. Teixeira

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 2.98 MB

english, 2012

14

Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development

Bruno M Fonseca, Georgina Correia-da-Silva, Anthony H Taylor, Justin C Konje, Stephen C Bell, Natércia A Teixeira

Journal:

Reproductive Biology and Endocrinology

Year:

2009

Language:

english

File:

PDF, 1.79 MB

english, 2009

15

Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy

Amaral, Cristina, Varela, Carla, Azevedo, Margarida, da Silva, Elisiário Tavares, Roleira, Fernanda M.F., Chen, Shiuan, Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 752 KB

english, 2013

16

Development of a new gas chromatography–mass spectrometry (GC–MS) methodology for the evaluation of 5α-reductase activity

Amaral, Cristina, Cunha, Sara C., Fernandes, José O., Tavares da Silva, Elisiário, Roleira, Fernanda M.F., Teixeira, Natércia, Correia-da-Silva, Georgina

Journal:

Year:

2013

Language:

english

File:

PDF, 3.03 MB

english, 2013

17

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors

Varela, Carla L., Amaral, Cristina, Correia-da-Silva, Georgina, Carvalho, Rui A., Teixeira, Natércia A., Costa, Saul C., Roleira, Fernanda M.F., Tavares-da-Silva, Elisiário J.

Journal:

Year:

2013

Language:

english

File:

PDF, 411 KB

english, 2013

18

Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis

Cristina Amaral, Carla Varela, Margarida Borges, Elisiário Tavares da Silva, Fernanda M. F. Roleira, Georgina Correia-da-Silva, Natércia Teixeira

Journal:

Year:

2013

Language:

english

File:

PDF, 690 KB

english, 2013

19

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line

Amaral, Cristina, Varela, Carla, Correia-da-Silva, Georgina, Tavares da Silva, Elisiário, Carvalho, Rui A., Costa, Saul C.P., Cunha, Sara C., Fernandes, José O., Teixeira, Natércia, Roleira, Fernanda

Journal:

Year:

2013

Language:

english

File:

PDF, 701 KB

english, 2013

20

Insights into the Synthesis of Steroidal A -Ring Olefins

Varela, Carla L., Roleira, Fernanda M. F., Costa, Saul C. P., Pinto, Alexandra S. C. T., Martins, Ana I. O. S., Carvalho, Rui A., Teixeira, Natércia A., Correia-da-Silva, Georgina, Tavares-da-Silva, E

Journal:

Helvetica Chimica Acta

Year:

2014

Language:

english

File:

PDF, 197 KB

english, 2014

21

MEDICAL DIARY OF THE WEEK.

Fonseca, Bruno M., Correia-da-Silva, Georgina, Teixeira, Natércia A.

Journal:

Year:

1857

Language:

english

File:

PDF, 216 KB

english, 1857

22

The rat as an animal model for fetoplacental development: a reappraisal of the post-implantation period

Fonseca, Bruno M., Correia-da-Silva, Georgina, Teixeira, Natércia A.

Journal:

Reproductive Biology

Year:

2012

Language:

english

File:

PDF, 610 KB

english, 2012

23

Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids

Cepa, Margarida, Correia-da-Silva, Georgina, Tavares da Silva, Elisiário J., Roleira, Fernanda M.F., Hong, Yanyan, Chen, Shiuan, Teixeira, Natércia A.

Journal:

Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 223 KB

english, 2008

24

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line

Varela, Carla L., Amaral, Cristina, Tavares da Silva, Elisiário, Lopes, Andreia, Correia-da-Silva, Georgina, Carvalho, Rui A., Costa, Saul C.P., Roleira, Fernanda M.F., Teixeira, Natércia

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.36 MB

english, 2014

25

Translating endoplasmic reticulum biology into the clinic: a role for ER-targeted natural products?

Pereira, David M., Valentão, Patrícia, Correia-da-Silva, Georgina, Teixeira, Natércia, Andrade, Paula B.

Journal:

Natural Product Reports

Year:

2015

Language:

english

File:

PDF, 922 KB

english, 2015

26

Lipidomic approach towards deciphering anandamide effects in rat decidual cell

Almada, Marta, Domingues, M. Rosário, Dória, M. Luísa, Fonseca, Bruno M., Teixeira, Natércia A., Correia-da-Silva, Georgina

Journal:

Journal of Cellular Physiology

Year:

2015

Language:

english

File:

PDF, 736 KB

english, 2015

27

The endocannabinoid anandamide affects the synthesis of human syncytiotrophoblast-related proteins

Costa, M. A., Fonseca, B. M., Mendes, A., Braga, J., Teixeira, N. A., Correia da Silva, Georgina

Journal:

Cell and Tissue Research

Year:

2015

Language:

english

File:

PDF, 499 KB

english, 2015

28

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane

Amaral, Cristina, Lopes, Andreia, Varela, Carla L., da Silva, Elisiário Tavares, Roleira, Fernanda M.F., Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2015

Language:

english

File:

PDF, 3.19 MB

english, 2015

29

Cannabinoid-induced autophagy: protective or death role?

Costa, Lia, Amaral, Cristina, Teixeira, Natércia, Georgina, Correia-da-Silva, Fonseca, Bruno Miguel

Journal:

Prostaglandins and Other Lipid Mediators

Year:

2015

Language:

english

File:

PDF, 981 KB

english, 2015

30

Unravelling exemestane: From biology to clinical prospects

Sobral, Ana Filipa, Amaral, Cristina, Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 389 KB

english, 2016

31

Exploring new chemical functionalities to improve aromatase inhibition of steroids

Varela, Carla L., Amaral, Cristina, Correia-da-Silva, Georgina, Costa, Saul C., Carvalho, Rui A., Costa, Giosuè, Alcaro, Stefano, Teixeira, Natércia A.A., Tavares-da-Silva, Elisiário J., Roleira, Fern

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.30 MB

english, 2016

32

Anti-tumor efficacy of new 7α-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells

Amaral, Cristina, Varela, Carla L., Maurício, João, Sobral, Ana Filipa, Costa, Saul C., Roleira, Fernanda M.F., Tavares-da-Silva, Elisiário J., Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2017

Language:

english

File:

PDF, 888 KB

english, 2017

33

The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor

Almada, Marta, Costa, Lia, Fonseca, Bruno Miguel, Amaral, Cristina, Teixeira, Natércia, Correia-da-Silva, Georgina

Journal:

Year:

2017

Language:

english

File:

PDF, 717 KB

english, 2017

34

Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity

Valente, Maria João, Amaral, Cristina, Correia-da-Silva, Georgina, Duarte, José Alberto, Bastos, Maria de Lourdes, Carvalho, Félix, Guedes de Pinho, Paula, Carvalho, Márcia

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 7.19 MB

english, 2017

35

The role of Soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects

Amaral, Cristina, Toloi, Maria Regina T., Vasconcelos, Luis Daniel, Fonseca, Maria J.V., Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

Food & Function

Year:

2017

Language:

english

File:

PDF, 1.52 MB

english, 2017

36

Unveilling the impact of Δ9-tetrahydrocannabinol (THC) on the endocrine function of human placenta: effects on estradiol production

Midão, Luis, Almada, Marta, Maia, João, Braga, Jorge, Gonçalves, Daniela, Teixeira, Natércia, Fonseca, Bruno, Correia-da-Silva, Georgina

Journal:

Year:

2017

Language:

english

File:

PDF, 66 KB

english, 2017

37

The endocannabinoid 2-arachidonoylglycerol (2-AG) induces endoplasmic reticulum stress in human cytotrophoblasts

Almada, Marta, Pereira, Sara, Fonseca, Bruno, Midão, Luis, Teixeira, Natércia, Correia-da-Silva, Georgina

Journal:

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

38

The endocannabinoid anandamide (AEA) impacts angiogenic ability of uterine NK cells from first trimester human placenta

Fonseca, Bruno M., Gonçalves, Daniela, Braga, Jorge, Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

Year:

2017

Language:

english

File:

PDF, 49 KB

english, 2017

39

Spontaneous abortion is associated with reduced mRNA of FPRL1 and GPR18 receptors in first trimester human placenta

Fonseca, Bruno M., Gonçalves, Daniela, Braga, Jorge, Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

Year:

2017

Language:

english

File:

PDF, 214 KB

english, 2017

40

Role of autophagy, apoptosis and oxidative stress in the toxicity of β-keto amphetamines to human dopaminergic SH-SY5Y cells

Valente, Maria João, Amaral, Cristina, Correia-da-Silva, Georgina, Duarte, José Alberto, de Lourdes Bastos, Maria, Carvalho, Félix, de Pinho, Paula Guedes, Carvalho, Márcia

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 60 KB

english, 2017

41

Prooxidant effects of synthetic cannabinoids on endometrial cells, results in a strenous rebound adaptative effect

Fonseca, Bruno M, Almada, Marta, Santos, Márcia, Gaspar, Helena, Carvalho, Felix, Teixeira, Natercia, Correia-da-Silva, Georgina

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 53 KB

english, 2018

42

Underpinning the endocannabinoid 2-AG induced-apoptosis in trophoblast cells: the role of oxidative stress

Almada, Marta, Maia, João, Pereira, Sara, Fonseca, Bruno, Teixeira, Natercia, Correia-da-Silva, Georgina

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 67 KB

english, 2018

43

Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance

Amaral, Cristina, Augusto, Tiago Vieira, Tavares-da-Silva, Elisiário, Roleira, Fernanda M.F., Correia-da-Silva, Georgina, Teixeira, Natércia

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.20 MB

english, 2018

44

The involvement of autophagy in the acquired resistance to third-generation aromatase inhibitors

Augusto, Tiago, Amaral, Cristina, Teixeira, Natércia, Correia-da-Silva, Georgina

Journal:

Free Radical Biology and Medicine

Year:

2018

Language:

english

File:

PDF, 57 KB

english, 2018

45

Apoptosis and Autophagy in Breast Cancer Cells following Exemestane Treatment

Amaral, Cristina, Borges, Margarida, Melo, Soraia, Silva, Elisiário Tavares da, Correia-da-Silva, Georgina, Teixeira, Natércia, Chellappan, Srikumar P.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.64 MB

english, 2012

46

Palmitic Acid and Ergosta-7,22-dien-3-ol Contribute to the Apoptotic Effect and Cell Cycle Arrest of an Extract from Marthasterias glacialis L. in Neuroblastoma Cells

Pereira, David, Correia-da-Silva, Georgina, Valentão, Patrícia, Teixeira, Natércia, Andrade, Paula

Journal:

Year:

2013

Language:

english

File:

PDF, 1.28 MB

english, 2013

47

Uterine histopathological changes induced by acute administration of tamoxifen and its modulation by sex steroid hormones

Sá, Susana I., Maia, João, Bhowmick, Niloy, Silva, Samuel M., Silva, Ana, Correia-da-Silva, Georgina, Teixeira, Natércia, Fonseca, Bruno M.

Journal:

Toxicology and Applied Pharmacology

Year:

2019

Language:

english

File:

PDF, 4.77 MB

english, 2019

48

Synthetic cannabinoids and endometrial stromal cell fate: Dissimilar effects of JWH-122, UR-144 and WIN55,212-2

Fonseca, Bruno M., Fernandes, Renata, Almada, Marta, Santos, Márcia, Carvalho, Félix, Teixeira, Natércia A., Correia-da-Silva, Georgina

Journal:

Year:

2019

Language:

english

File:

PDF, 2.00 MB

english, 2019

49

C-6α vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which is Better? Synthesis, Biochemical Evaluation, Docking Studies and Structure-Activity Relationships

Roleira, Fernanda Maria Fernandes, Varela, Carla, Amaral, Cristina, Costa, Saul C., Correia-da-Silva, Georgina, Moraca, Federica, Costa, Giosuè, Alcaro, Stefano, Teixeira, Natercia Almeida, Tavares da

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 979 KB

2019

50

A novel GC-MS methodology to evaluate aromatase activity in human placental microsomes: a comparative study with the standard radiometric assay

Augusto, Tiago V., Cunha, Sara C., Amaral, Cristina, Fernandes, José O., da Silva, Elisiário Tavares, Roleira, Fernanda F. M., Teixeira, Natércia, Correia-da-Silva, Georgina

Journal:

Analytical and Bioanalytical Chemistry

Year:

2019

Language:

english

File:

PDF, 783 KB

english, 2019

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